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Trials typically incorporate biomarker endpoints such as ER/ER ratios, aromatase activity, plasma isoflavone or polyphenol concentrations, immune cell phenotyping, cytokine panels, oxidative stress markers and microbiome profile which are used to provide mechanistic read-outs of supplement activity and to inform patient stratification approaches (231)

Available online: 182.Hampl S.E., Hassink S.G., Skinner A.C., Armstrong S.C., Barlow S.E., Bolling C.F., Avila Edwards K.C., Eneli I., Hamre R., Joseph M.M., et al

Toxicol Sci 153(1):124136 Muthuraman P, Ramkumar K, Kim DH (2014) Analysis of dose-dependent effect of zinc oxide nanoparticles on the oxidative stress and antioxidant enzyme activity in adipocytes

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